Description

Antirobe Capsules are a prescription antibiotic containing clindamycin hydrochloride for use in dogs. Clindamycin is a semisynthetic lincosamide antibiotic with activity against a variety of susceptible aerobic and anaerobic bacterial pathogens.

Antirobe Capsules are indicated for certain skin infections, including wounds and abscesses, dental infections, and osteomyelitis caused by susceptible bacteria.

Clindamycin is rapidly absorbed from the canine gastrointestinal tract and works by interfering with bacterial protein synthesis.

Uses & Benefits

• Treats certain bacterial skin infections in dogs
• May be prescribed for infected wounds and abscesses
• Treats certain susceptible dental infections
• Indicated for certain cases of osteomyelitis
• Active against susceptible aerobic and anaerobic bacterial pathogens
• Oral capsule formulation for convenient administration
• FDA-approved specifically for use in dogs

How It Works

Antirobe contains clindamycin, a lincosamide antimicrobial agent.

Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. This interferes with the ability of susceptible bacteria to produce proteins necessary for growth and survival.

Clindamycin has activity against a variety of susceptible aerobic and anaerobic bacterial pathogens.

Indications

For use in dogs only.

Antirobe Capsules are indicated for the treatment of infections caused by susceptible strains of designated microorganisms in the following conditions:

Skin Infections

Including wounds and abscesses associated with susceptible:

• Staphylococcus aureus / Staphylococcus intermedius / Bacteroides fragilis / Prevotella melaninogenicus / Fusobacterium necrophorum / Clostridium perfringens

Dental Infections

Associated with susceptible:

• Staphylococcus aureus / Bacteroides fragilis / Prevotella melaninogenicus / Fusobacterium necrophorum / Clostridium perfringens

Osteomyelitis

Associated with susceptible:

• Staphylococcus aureus / Bacteroides fragilis / Prevotella melaninogenicus / Fusobacterium necrophorum / Clostridium perfringens

Ingredients

Active Ingredients:

Clindamycin Hydrochloride, equivalent to clindamycin.

Inactive Ingredients:

The current FDA/DailyMed label for Antirobe Capsules does not provide an inactive ingredient list for the capsule formulation.

Refer to manufacturer label for complete inactive ingredient information.

Directions

Administer orally exactly as prescribed by your veterinarian.

The appropriate dose and duration depend on the type and severity of the infection.

For infected wounds, abscesses, and dental infections, treatment may be continued for up to 28 days if clinical judgment indicates. Treatment of acute infections should not continue for more than 3 to 4 days if no response to therapy is seen.

For osteomyelitis, treatment is recommended for a minimum of 28 days. Treatment should not continue longer than 28 days if no response to therapy is seen.

Always complete treatment according to your veterinarian's instructions.

Weight / Dosage

Infected Wounds, Abscesses & Dental Infections

• Dogs: 2.5–15 mg/lb of body weight orally every 12 hours.

Osteomyelitis

• Dogs: 5–15 mg/lb of body weight orally every 12 hours.

The veterinarian should determine the appropriate dose within these ranges based on the dog's condition and response to treatment.

Administer exactly as prescribed by your veterinarian. Follow all dosing and administration instructions provided on the prescription label and by your veterinarian. Do not adjust the dose, frequency, route, or duration of administration unless directed by your veterinarian.

Cautions

• For veterinary use only.
• Federal law restricts this drug to use by or on the order of a licensed veterinarian.
• Antirobe Capsules are labeled for use in dogs only.
• Do not use in animals with a history of hypersensitivity to preparations containing clindamycin or lincomycin.
• Because of the potential for serious gastrointestinal effects, Antirobe should not be administered to rabbits, hamsters, guinea pigs, horses, chinchillas, or ruminating animals.
• Keep out of reach of children. Not for human use.

Possible Side Effects

Side effects occasionally observed during clinical trials or clinical use include:

• Vomiting / Diarrhea

Clindamycin may also result in overgrowth of non-susceptible organisms, including certain clostridia and yeasts.

Contact your veterinarian if your dog develops persistent vomiting, diarrhea, significant gastrointestinal upset, or another concerning reaction during treatment.

Precautions

• Use only as directed by a licensed veterinarian
• Do not administer to animals with known hypersensitivity to clindamycin or lincomycin
• Do not administer to rabbits, hamsters, guinea pigs, horses, chinchillas, or ruminating animals
• During prolonged therapy of one month or longer, periodic liver and kidney function tests and blood counts should be performed
• Use cautiously in patients with very severe kidney or liver disease accompanied by severe metabolic abnormalities
• Clindamycin has neuromuscular blocking properties and should be used cautiously with other neuromuscular blocking agents
• Safety in gestating bitches or breeding male dogs has not been established
• Monitor for overgrowth of non-susceptible organisms during treatment

Storage

Store at controlled room temperature between 68°F and 77°F (20°C to 25°C). Keep securely out of reach of children and animals.

Disposal

Dispose of unused or expired medication through an appropriate medication take-back program when available.
If a take-back program is unavailable, follow disposal recommendations provided by your veterinarian, pharmacist, manufacturer label, or local authorities.
Do not use medication beyond its expiration date.