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SILEO (dexmedetomidine oromucosal gel) Syringe

SILEO (dexmedetomidine oromucosal gel) Syringe
0.1mg/mL, 3 mL - Syringe - on Manufacturer Backorder; ETA 7/11/24
SKU : 64603_-RX
Price: $32.98
Price: $32.98
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Veterinarian Prescription (Rx) Required
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  • Indicated for the treatment of noise aversion in dogs (signs related to anxiety or fear due to noise)
  • Calms without sedating, which allows your dog to interact normally with the family.
  • A practical, fast-acting, easy-to-administer at-home treatment for noise aversion
  • Available Size
    • 0.1mg/mL - 3mL Syringe
*Manufacturer restricts additional discounts on this item unless explicitly specified
How to Order Prescriptions


Sileo a prescription gel that is given to dogs by mouth to treat noise aversion (signs related to anxiety or fear due to noise). 

Sileo is packaged in an oral dosing syringe with a ring-stop mechanism on the plunger that must be “dialed” and locked into place in order to set the correct dose for the dog. Overdose can result if the ring-stop is not fully locked. Therefore, it is very important that the person administering the product understands how to operate the syringe correctly before giving the product to the dog. 


    • First FDA-Approved treatment for noise aversion in dogs
    • Calming without sedating, allowing for normal dog-owner interactions
    • Easy to administer at home, when needed
    • Works on its own without any other treatments or training
    • Quick onset of action
    • Supports early intervention for optimal effect on the quality of life of the dog
    • Effective for up to 3 hours

How it works

Sileo is an oromucosal gel formulation of dexmedetomidine hydrochloride provided in a 3 ml syringe at a concentration of 0.1 mg/ml. Using the syringe, Sileo is easily administered between the cheek and gum, allowing for transmucosal absorption. Because Sileo is formulated to provide a low dose of dexmedetomidine, your dog remains calm, yet fully functional, and is able to interact normally with your family.


How to administer SILEO correctly

Further dosing

Dosage and Administration

SILEO is administered onto the oral mucosa between the dog’s cheek and gum at the dose of 125 mcg/m2. The gel is absorbed through the oral mucosa and therefore it should NOT be swallowed. If the gel is swallowed, the product may not be effective. If the gel is swallowed, do not repeat the dose for at least two hours. 

All prescribing veterinarians and users should be aware of the possibility for accidental overdose if the Sileo syringe is not properly locked before dosing. Veterinary staffs are strongly encouraged to provide education in proper operation of the syringe to dog owners before dispensing the drug. Dog owners should be aware of potential signs of overdose and they should contact their veterinarian if their dog exhibits any of these signs.