Vetoryl (Trilostane) Capsules

Vetoryl (Trilostane) Capsules
5 mg, 30 ct. - Capsule
10 mg, 30 ct. - Capsule
30 mg, 30 ct. - Capsule
60 mg, 30 ct. - Capsule
120 mg, 30 ct. - Capsule
SKU : 300705_-RX
Price: $49.99
Price: $49.99

Veterinarian Prescription (Rx) Required
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  • Trilostane
  • Adrenocortical suppressant
  • Treats Cushing’s syndrome in dogs
  • For oral use in dogs only

How to Order Prescriptions

Description

VETORYL Capsules are available in 3 sizes (10, 30 and 60 mg) for oral administration based on body weight. Trilostane (4α, 5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone. This inhibition blocks production of glucocorticoids and to a lesser extent, mineralocorticoids and sex hormones while steroid precursor levels increase.

Why Vetoryl Capsules?

    • Contain the active ingredient trilostane.
    • Trilostane blocks the excessive production of cortisol by reversibly inhibiting the action of the enzyme 3-ß hydroxysteroid dehydrogenase.
    • While treatment with trilostane significantly reduces serum cortisol concentrations, it has not been found to reduce aldosterone significantly.†
Adrenocortical suppressant for oral use in dogs only.

 

Indications

    • VETORYL Capsules are indicated for the treatment of pituitary-dependent hyperadrenocorticism in dogs.
    • VETORYL Capsules are indicated for the treatment of hyperadrenocorticism due to adrenocortical tumor in dogs.

Dosage and Administration

Always provide the Client Information Sheet with prescription. The starting dose for the treatment of hyperadrenocorticism in dogs is 1.0-3.0 mg/lb (2.2-6.7 mg/kg) once a day based on body weight and capsule size (see Table 1). VETORYL Capsules should be administered with food.

After approximately 10-14 days at this dose, re-examine the dog and conduct a 4-6 hour post-dosing ACTH stimulation test and serum biochemical tests (with particular attention to electrolytes, and renal and hepatic function). If physical examination is acceptable, take action according to Table 1.

Owners should be instructed to stop therapy and contact their veterinarian immediately in the event of adverse reactions such as vomiting, diarrhea, lethargy, poor/reduced appetite, weakness, collapse or any other unusual developments. If these clinical signs are observed, conduct an ACTH stimulation test and serum biochemical tests (with particular attention to electrolytes, and renal and hepatic function

 

Dosage Table

Weight

Dosage

3.8 to 10 lbs

One 10 mg capsule daily

10 to 22 lbs

One 30 mg capsule daily

22 to 44 lbs

One 60 mg capsule daily

44 to 88 lbs

One 120 mg capsule daily

88 to 132 lbs

One 120 mg capsule of 120 mg and one 60 mg capsule daily (180 mg total)

Over 132 lbs

Administer the appropriate amount of capsules based on dog's weight. Speak with your veterinarian to help you determine the correct dosage for your dog.


Storage Directions

Store at room temperature 25°C (77°F) with excursions between 15°- 30°C (59°- 86°F) permitted. Keep out of reach of children and pets.

 

Human Warnings

Keep out of reach of children. Not for human use.

Wash hands after use. Do not empty capsule contents and do not attempt to divide the capsules. Do not handle the capsules if pregnant or if trying to conceive. Trilostane is associated with teratogenic effects and early pregnancy loss in laboratory animals. In the event of accidental ingestion/overdose, seek medical advice immediately and take the labeled container with you.

Contraindications

The use of Vetoryl Capsules is contraindicated in dogs that have demonstrated hypersensitivity to trilostane. Do not use Vetoryl Capsules in animals with primary hepatic disease or renal insufficiency . Do not use in pregnant dogs. Studies conducted with trilostane in laboratory animals have shown teratogenic effects and early pregnancy loss.

Possible Side Effects

If any of the following serious side effects occur, stop giving Vetoryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), severe depression, bloody diarrhea, collapse, or other severe reactions. Other less serious side effects such as unexpected decrease in appetite, vomiting, diarrhea, and lethargy may occur. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your dog.

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