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Simparica (Sarolaner) Chews for Dogs

Simparica (Sarolaner) Chews for Dogs
2.8-5.5 lbs, 3 months - Gold - 3 chews
2.8-5.5 lbs, 6 months - Gold - 6 chews
5.6-11.0 lbs, 3 months - Purple - 3 chews
5.6-11.0 lbs, 6 months - Purple - 6 chews
11.1-22.0 lbs, 3 months - Orange - 3 chews
11.1-22.0 lbs, 6 months - Orange - 6 chews
22.1-44.0 lbs, 3 months - Teal - 3 chews
22.1-44.0 lbs, 6 months - Teal - 6 chews
44.1-88.0 lbs, 3 months - Green - 3 chews
44.1-88.0 lbs, 6 months - Green - 6 chews
88.1-132.0 lbs, 3 months - Brown - 3 chews
88.1-132.0 lbs, 6 months - Brown - 6 chews
SKU : 6600_-RX
Price: $59.48
Price: $59.48
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  • ​Safe monthly chewable for dogs
  • Protection from fleas and ticks
  • Starts killing fleas within 3 hours
  • Starts killing ticks within 8 hours
*Manufacturer restricts additional discounts on this item unless explicitly specified
How to Order Prescriptions


Simparica™ (sarolaner) chewables are a safe monthly chewable for dogs that offers persistent protection from fleas and ticks. Simparica™ acts fast - starts killing fleas within 3 hours and ticks within 8 hours. Each chewable contains 5 mg of sarolaner.

Simparica™ is a flavored, chewable tablet for administration to dogs over 6 months of age according to their weight. Each tablet is formulated to provide a minimum sarolaner dosage of 0.91 mg/lb (2 mg/kg) body weight.



    • Easy-to-administer chewable tablet delivers fast and persistent protection over 35 days from fleas and ticks, without losing efficacy at the end of the month.
    • Each tablet provides a full month of protection against fleas and ticks
    • Tasty, liver-flavored chewable tablet is easy to administer
    • Chewable tablets can be given directly to your dog or broken up and mixed with food
    • Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs


    • Simparica™ (sarolaner) Chewables are safe, monthly flea and tick protection for dogs that start working fast and remain effective all month long.
    • Simparica™ starts killing fleas within 3 hours and ticks within 8 hours,* and it keeps going strong for 35 days* without losing effectiveness at the end of the month.

Proven persistent protection against fleas and ticks.

Simparica is effective against fleas and ticks, even on day 35!* You can count on Simparica to do the following:
    • Provide rapid relief for pets with existing flea infestations, even dogs with flea allergies
    • Improve clinical signs of flea allergies in dogs by eliminating fleas
    • Prevent and control home flea infestations, killing fleas before they can lay eggs
    • Quickly kill ticks, which may help reduce the risk of potentially life-threatening flea- and tick-borne diseases

Why switch to Simparica?

Simparica provides peak protection all month long, 7-20 with no decrease in effectiveness like some other brands.



Dosage and Administration

SIMPARICA is given orally once a month at the recommended minimum dosage of 0.91 mg/lb (2 mg/kg). 

Body Weight SAROLANER per Tablet (mg) Number of Tablets Administered
2.8 to 5.5 lbs 5 One
5.6 to 11.0 lbs 10 One
11.1 to 22.0 lbs 20 One
22.1 to 44.0 lbs 40 One
44.1 to 88.0 lbs 80 One
88.1 to 132.0 lbs 120 One
>132.1 lbs Administer the appropriate combination of tablets


In a well-controlled laboratory study, SIMPARICA began to kill fleas 3 hours after initial administration and reduced the number of live fleas by ≥96.2% within 8 hours after flea infestation through Day 35.
In a separate well-controlled laboratory study, SIMPARICA demonstrated 100% effectiveness against adult fleas within 24 hours following treatment and maintained 100% effectiveness against weekly re-infestations for 35 days.In a study to explore flea egg production and viability, SIMPARICA killed fleas before they could lay eggs for 35 days. In a study to simulate a flea-infested home environment, with flea infestations established prior to the start of treatment and re-infestations on Days 7, 37 and 67, SIMPARICA administered monthly for three months demonstrated >95.6% reduction in adult fleas within 14 days after treatment and reached 100% on Day 60.
In well-controlled laboratory studies, SIMPARICA demonstrated ≥99% effectiveness against an initial infestation of Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhipicephalus sanguineus 48 hours post-administration and maintained >96% effectiveness 48 hours post re-infestation for 30 days.
In a well-controlled 90-day US field study conducted in households with existing flea infestations of varying severity, the effectiveness of SIMPARICA against fleas on Day 30, 60 and 90 visits compared to baseline was 99.4%, 99.8%, and 100%, respectively. Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus as a direct result of eliminating fleas.

SIMPARICA can be offered by hand, in the food, or administered like other tablet medications. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. If a dose is missed, administer SIMPARICA and resume a monthly dosing schedule. SIMPARICA should be administered at monthly intervals.


SIMPARICA kills adult fleas, and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs 6 months of age or older and weighing 2.8 pounds or more.

Side Effects

Side effects may include abnormal neurologic signs such as tremors, decreased conscious proprioception, ataxia, decreased or absent menace, and/or seizures. Notify your veterinarian if side effects appear and remain troublesome. Other side effects may occur, if you notice anything unusual, contact your veterinarian.


Not for use in humans. Keep this and all drugs out of reach of children and pets. For use in dogs only. Do not use Simparica™ in cats. Simparica™ has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica™ has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications.