ClomiPRAMINE Hydrochloride Capsules

Description

Clomipramine Hydrochloride Capsules are a prescription tricyclic antidepressant that may be prescribed by veterinarians for dogs and cats with certain behavioral disorders.

Clomipramine affects neurotransmitter activity within the central nervous system, particularly serotonin. Veterinarians may prescribe it for separation-related behaviors, compulsive behaviors, and other behavioral conditions when medication is appropriate.

These capsules are human-labeled prescription medication. Veterinary use is extra-label and should be directed and monitored by a licensed veterinarian. Medication is generally most effective for behavioral conditions when incorporated into an appropriate behavior modification and environmental management plan.

Uses & Benefits

• Prescription medication for veterinarian-diagnosed behavioral conditions
• May help manage separation-related behaviors
• May be prescribed for compulsive or repetitive behaviors
• Helps modify serotonin activity within the central nervous system
• May be incorporated into a comprehensive behavior modification program
• Can be prescribed for dogs or cats when considered appropriate by a veterinarian

How It Works

Clomipramine belongs to the tricyclic antidepressant class of medications. Its behavioral effects are thought to be associated primarily with inhibition of serotonin reuptake within the central nervous system.

By altering serotonergic neurotransmission, clomipramine may help reduce certain anxiety-related, compulsive, or repetitive behaviors when prescribed for an appropriate behavioral diagnosis.

Indications

Veterinarians may prescribe clomipramine extra-label for behavioral conditions in dogs and cats when medication is considered appropriate.

Separation-Related Behaviors / Compulsive or Repetitive Behaviors / Anxiety-Related Behaviors / Other Veterinarian-Diagnosed Behavioral Conditions

Ingredients

Active Ingredients:

Clomipramine Hydrochloride

Inactive Ingredients:

Inactive ingredients vary by manufacturer and capsule formulation. Refer to the dispensed manufacturer's labeling for complete inactive ingredient information.

Directions

Follow the prescription label exactly and veterinarian directions.

Administer orally exactly as prescribed by your veterinarian. Clomipramine may be given with or without food. Giving the medication with food may be helpful if gastrointestinal upset occurs.

Do not change the dose, frequency, or duration of treatment without consulting your veterinarian. Do not abruptly discontinue long-term therapy unless directed by your veterinarian.

Behavioral improvement may not be immediate. Continue administering the medication as prescribed and follow any behavior modification program recommended by your veterinarian.

Cautions

• Prescription medication.
• Use only under the direction of a licensed veterinarian.
• Do not use in animals with known hypersensitivity to clomipramine or other tricyclic antidepressants.
• Use caution in animals with cardiovascular disease, seizure disorders, urinary retention, glaucoma, gastrointestinal motility disorders, liver disease, or other significant medical conditions.
• Tell your veterinarian about all medications and supplements your pet receives before starting treatment.
• Potentially significant interactions can occur with monoamine oxidase inhibitors, other antidepressants, serotonergic medications, anticholinergic drugs, and certain other medications.
• Keep medication securely out of reach of children and animals. Accidental overdose can be serious.

Possible Side Effects

Drowsiness or Sedation / Vomiting / Diarrhea / Decreased Appetite / Dry Mouth / Constipation / Changes in Urination / Restlessness / Behavioral Changes / Increased Heart Rate

Contact your veterinarian if side effects are persistent, severe, or concerning. Seek prompt veterinary attention for seizures, collapse, abnormal heart rhythm, severe agitation, tremors, marked weakness, or suspected overdose.

Precautions

Clomipramine should be used as part of an individualized veterinary treatment plan. Behavioral problems can have medical, environmental, and behavioral causes, so veterinary evaluation is important before and during treatment.

Use cautiously in animals with underlying cardiovascular, neurologic, hepatic, urinary, gastrointestinal, or ophthalmic conditions.

Safety during breeding, pregnancy, and lactation has not been established for extra-label veterinary use. Discuss use in breeding, pregnant, or nursing animals with your veterinarian.

Because clomipramine can interact with other medications, provide your veterinarian with a complete list of prescription medications, over-the-counter products, preventatives, and supplements your pet receives.

Storage

Store at controlled room temperature and protect from moisture. Keep capsules in a tight, light-resistant container unless otherwise directed by the dispensing label.

Disposal

Dispose of unused or expired Clomipramine Hydrochloride Capsules through a medication take-back program when available or according to applicable local medication disposal requirements. Keep discarded medication and packaging securely inaccessible to children and animals.