Cool Down With 10% Off Hundreds Of Pet Products With Code SUMMER10

Zycosan (Pentosan Polysulfate Sodium) Injection

Zycosan (Pentosan Polysulfate Sodium) Injection
250mg/mL, 7.5 mL - Single Vial
250mg/mL, 7.5 mL - 4 Pack - 4 Vials
SKU : 32707_-RX
Price: $99.75
Price: $99.75
Save 15% on your first Autoship order
+ Save on each recurring order!

Veterinarian Prescription (Rx) Required
Free Shipping on orders over $75
Low Price Match Guarantee

  • Control of clinical signs associated with osteoarthritis in horses.
How to Order Prescriptions


Zycosan is used for the control of clinical signs associated with osteoarthritis in horses.

Dosage and Administration

Administer 3 mg/kg (1.4 mg/lb) by intramuscular injection once weekly. Zycosan is provided in a single use vial and does not contain a preservative. Discard unused vial contents.


Horses with hypersensitivity to pentosan polysulfate sodium or any of the inactive ingredients in Zycosan should not receive Zycosan. Do not use Zycosan concurrently with other anticoagulant drugs. Do not use in horses with clotting disorders or within 24 hours of surgical procedures (see Warnings and Precautions).

Warnings and Precautions

Zycosan has been shown to prolong coagulation parameters up to 24 hours after injection, therefore caution should be used when administering this drug before or after strenuous activities (see Target Animal Safety). Due to the anticoagulant effects, this drug may exacerbate Exercise Induced Pulmonary Hemorrhage (EIPH). The concurrent use of NSAIDs with Zycosan has not been evaluated. Due to the anticoagulant effects of Zycosan and known anticoagulant effects of some NSAIDs, caution should be used if NSAIDs are concurrently administered. Horses concurrently treated with Zycosan and NSAIDs should be monitored for hemorrhage or other clinical signs of abnormal bleeding (e.g., petechiae, ecchymosis, or epistaxis). The safety of long-term repeat use of Zycosan has not been evaluated. Pigmentary changes in the retina (pigmentary maculopathy) have been reported in human patients following long-term oral use of pentosan polysulfate sodium. It is not known if a similar finding occurs in horses. The safe use of Zycosan has not been evaluated in breeding, pregnant, or lactating horses.


Store at room temperature 68-77°F (20-25°C), with excursions to 59-86°F (15-30°C).