Senergy (selamectin) Topical Parasiticide

Senergy (selamectin) Topical Parasiticide
Kittens and Puppies Up to 5 lbs, 3 month - (mauve) - 3 doses
Cats 5.1 to 15 lbs, 3 month - (blue) - 3 doses
Cats 15.1 to 22 lbs, 3 month - (taupe) - 3 doses
Dogs 5 to 10 lbs, 3 month - Toy (lavender)- 3 doses
Dogs 10.1 to 20 lbs, 3 month - Small (brown) - 3 doses
Dogs 20.1 to 40 lbs, 3 month - Medium (red) - 3 doses
Dogs 40.1 to 85 lbs, 1 month - Large (teal) - 1 dose (SINGLE): Expiration 10/21
Dogs 40.1 to 85 lbs, 3 month - Large (teal) - 3 doses
Dogs 85.1 to 130 lbs, 1 month - X-Large (plum) - 1 dose (SINGLE): Expiration 10/21
Dogs 85.1 to 130 lbs, 3 month - X-Large (plum) - 3 doses
SKU : 50090_-RX
Price: $41.34
Price: $41.34

New from Virbac!

Veterinarian Prescription (Rx) Required
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  • Selamectin is the  #1 vet-recommended  feline parasiticide
  • Trusted profection from a trusted partner
  • Offers parasite protection for kittens, cats, puppies, and dogs

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Description

SENERGY™ (selamectin) Topical Parasiticide, the new smart option from Virbac, offers parasite protection* for kittens, cats, puppies, and dogs  that can be used all year—all at a great value! Selamectin is the  #1 vet-recommended  feline parasiticide. Over 6 million treatments have been dispensed for cats in 2018 and it can be used to protect dogs against certain parasites, too! SENERGY (selamectin)

Topical Parasiticide is available as a colorless to yellow, ready to use solution in single dose tubes  for topical (dermal) treatment of dogs six weeks of age and older and cats eight weeks of age and older. The content of each tube  is formulated to provide a minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin. The chemical composition of selamectin  is (5Z,25S)-25-cyclohexyl-4’-O-de(2,6-dideoxy-3-O-methyl-α-L- arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22, 23-dihydro-5-hydroxyiminoavermectin A1a. 

Benefits

    • Essential protection for cats, both indoor and out
    • Trusted for kitten ( ≥ 8 weeks of age) and puppies  ( ≥ 6 weeks of age) and their mothers
    • Suitable to use during pet's pregnancy and lactation

Important Safety Information

SENERGY™ (selamectin) is well tolerated. All dogs and cats should  be tested for heartworm disease before starting a preventive protocol. Use only on cats 8 weeks  and older and on dogs 6 weeks and older. Digestive and skin side effects have been reported.  In people, SENERGY may be irritating to the skin and eyes. Wash hands after use. For complete prescribing information, contact Virbac at 1-800-338-3659, or us.virbac.com. 

Caution

US Federal law restricts this drug to use by or on the order of  a licensed veterinarian.

Indications

SENERGY is recommended for use in dogs six weeks of age or  older and cats eight weeks of age and older for the following parasites and indications

Dogs

SENERGY kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. SENERGY also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

Cats

SENERGY kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. SENERGY is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

Warnings

Not for human use. Keep out of the reach of children.  In humans, SENERGY may be irritating to skin and eyes.  Reactions such as hives, itching and skin redness have been reported in humans in rare instances. Individuals with known hypersensitivity to SENERGY should use the product with caution or consult a health care professional. SENERGY contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water. In case of ingestion by a human, contact a physician immediately. The safety data sheet (SDS) provides more detailed occupational safety information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Virbac AH, Inc. at 1-800-338-3659 or us.virbac.com. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS  or http://www.fda.gov/reportanimalae. Flammable - Keep away from heat, sparks, open flames or other sources of ignition. Do not use in sick, debilitated or underweight animals  (see SAFETY).

Precautions

Prior to administration of SENERGY, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Selamectin is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, selamectin is not effective for microfilariae clearance. Hypersensitivity reactions have not been observed in dogs with patent heartworm infections administered three times the recommended dose of selamectin. Higher doses were not tested.

Adverse Reactions

Pre-approval clinical trials: Following treatment with selamectin, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Other signs observed rarely (≤0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors. Post-approval experience: In addition to the aforementioned clinical signs that were reported in pre-approval clinical trials, there have been reports of pruritus, urticaria, erythema, ataxia, fever, and rare reports of death. There have also been rare reports of seizures in dogs (see WARNINGS).

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight. Administer the entire contents of a single dose tube (or two  tubes used in combination for dogs weighing over 130 pounds)  of SENERGY topically in accordance with the following tables. (See ADMINISTRATION for the recommended treatment intervals.)

Cats (lb)

Package Color

Mg per tube

Potency (mg/mL)

Administered volume (mL)

Up to 5

Mauve

15 mg

60

0.25

5.1-15

Blue

45 mg

60

0.75

15.1-22

Taupe

60 mg

60

1.0

For cats over 22 lbs use the appropriate combination of tubes.

Dogs (lb)

Package Color

Mg per tube

Potency (mg/mL)

Administered volume (mL)

Up to 5

Mauve

15 mg

60

0.25

5.1-10

Lavender

30 mg

120

0.25

10.1-20

Brown

60 mg

120

0.5

20.1-40

Red

120 mg

120

1.0

40.1-85

Teal

240 mg

120

2.0

85.1-130

Plum

360 mg

120

3.0

For dogs over 130 lbs use the appropriate combination of tubes. Recommended for use in dogs 6 weeks of age and older and in cats 8 weeks of age and older.

Administration

A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying SENERGY topically to dogs and cats prior to first use. Remove the tube from the package and hold upright with the lot and expiration at the bottom. Bend the tip back until it snaps off. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of SENERGY against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of SENERGY against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of SENERGY against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse.

Flea Control in Dogs and Cats

For the prevention and control of flea infestations, SENERGY should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. In controlled laboratory studies >98% of fleas were killed within 36 hours. Results of clinical field studies using selamectin monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with selamectin, including those with preexisting flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment. If the dog or cat is already infested with fleas when the first dose of selamectin is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. However, an environmental infestation of fleas may persist for a short time after beginning treatment with selamectin because of the emergence of adult fleas from pupae.

Heartworm Prevention in Dogs and Cats

For the prevention of heartworm disease, SENERGY must be administered on a monthly basis. SENERGY may be administered year-round or at least within one month after the animal’s first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of SENERGY and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of SENERGY must be given within a month of the last dose of the former medication. Selamectin, the active ingredient in SENERGY, is a macrocyclic lactone compond. These componds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using SENERGY beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at >8 weeks of age), or gaps of >2 months in the administration of SENERGY during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of SENERGY may be harboring pre-patent infections at the time SENERGY was started. Testing such animals 3–4 months after initiation of SENERGY would be necessary to confirm their negative heartworm status. At the discretion of the veterinarian, cats ≥6 months of age may be  tested to determine the presence of existing heartworm infections  before beginning treatment with SENERGY. Cats already infected  with adult heartworms can be given SENERGY monthly to prevent further infections.

Ear Mite Treatment in Dogs and Cats

For the treatment of ear mite (O. cynotis) infestations in dogs and cats, SENERGY should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of SENERGY will control any subsequent ear mite infestations. In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the second dose. Cleansing of the infested ears is recommended to remove the debris.

Sarcoptic Mange Treatment in Dogs

For the treatment of sarcoptic mange (S. scabiei) in dogs, SENERGY should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of SENERGY will control any subsequent sarcoptic mange mite infestations. Because of the difficulty in finding sarcoptic mange mites on skin scrappings, effectiveness assessments also were based on resolution of clinical signs. Resolution of the pruritus associated with the mite infestations was observed in approximately 50% of the dogs 30 days after the first treatment and in approximately 90% of the dogs 30 days after the second monthly treatment.

Tick Control in Dogs

For the control of tick (Dermacentor variabilis) infestations in dogs, SENERGY should be administered on a monthly basis. In heavy tick infestations, complete efficacy may not be achieved after the first dose. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter.

Nematode Treatment in Cats

For the treatment and control of intestinal hookworm  (A. tubaeforme) and roundworm (T. cati) infections,  SENERGY should be applied once as a single topical dose.

Safety

Selamectin has been tested safe in over 100 different pure and mixed breeds of healthy dogs and over 15 different pure and mixed breeds of healthy cats, including pregnant and lactating females, breeding males and females, puppies six weeks of age and older, kittens eight weeks of age and older, and avermectin-sensitive collies. A kitten, estimated to be 5–6 weeks old (0.3 kg), died  8 1/2 hours after receiving a single treatment of selamectin at the recommended dosage. The kitten displayed clinical signs which included muscle spasms, salivation and neurological signs. The kitten was a stray with an unknown history and was malnourished and underweight (see WARNINGS).

Dogs

In safety studies, selamectin was administered at 1, 3, 5, and 10 times the recommended dose to six-week-old puppies, and no adverse reactions were observed. The safety of selamectin administered orally also was tested in case of accidental oral ingestion. Oral administration of selamectin at the recommended topical dose in 5- to 8-month-old beagles did not cause any adverse reactions. In a pre-clinical study selamectin was dosed orally to ivermectin-sensitive collies. Oral administration of 2.5, 10, and  15 mg/kg in this dose escalating study did not cause any adverse reactions; however, eight hours after receiving 5 mg/kg orally, one avermectin-sensitive collie became ataxic for several hours, but did not show any other adverse reactions after receiving subsequent doses of 10 and 15 mg/kg orally. In a topical safety study conducted with avermectin-sensitive collies at 1, 3 and 5 times the recommended dose of selamectin, salivation was observed in all treatment groups, including the vehicle control. Selamectin also was administered at 3 times the recommended dose to heartworm infected dogs, and no adverse effects were observed.

Cats

In safety studies, selamectin was applied at 1, 3, 5, and 10 times the recommended dose to six-week-old kittens. No adverse reactions were observed. The safety of selamectin administered orally also was tested in case of accidental oral ingestion. Oral administration of the recommended topical dose of selamectin to cats caused salivation and intermittent vomiting. Selamectin also was applied at 4 times the recommended dose to patent heartworm infected cats, and no adverse reactions were observed. In well-controlled clinical studies, selamectin was used safely in animals receiving other frequently used veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

Storage Conditions

Store below 25°C (77°F).

How Supplied

Available in eight separate dose strengths for dogs and cats of different weights (see DOSAGE). SENERGY for puppies and kittens is available in cartons containing 3 single dose tubes. SENERGY for cats and dogs is available in cartons containing 3 single dose tubes.
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