Semintra Oral Solution

How to Order Prescriptions

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Description

Semintra Oral Solution is for the reduction of proteinuria in cats with chronic kidney disease. It is given from a syringe so it is easy to administer. Semintra begins to work quickly. The levels of protein in your cat's urine will reduce within 7 days of starting treatment.  If you are to miss a dose, do not increase the dose or dose frequency - just wait to administer again until the next scheduled dose is due and give as normal. 

Your cat may require life-long treatment for chronic kidney disease, but many cats live happily for a number of years after diagnosis!

Key Features

• Controls systemic hypertension in cats
• Easy to give liquid formula
• Give directly by mouth, or next to or on top of a small amount of food

How It Works

Semintra (telmisartan oral solution) is a clear, colorless to yellowish viscous solution containing 10 mg/mL telmisartan. Telmisartan is an orally active, non-peptide, selective angiotensin II subtype 1 (AT1) receptor blocker, which helps control hypertension.

Indications

SEMINTRA is indicated for the control of systemic hypertension in cats.

Directions

Always provide the Client Information Sheet with each prescription.

Hypertension in Cats

A silent disease

While hypertension can be a common problem in older cats, the condition can be difficult to diagnose.

Hypertension can affect many parts of the body before detection and is strongly associated with target organ damage.

• Eyes
• Heart and vascular system
• Brain
• Kidneys

Without treatment, this silent disease can lead to serious illness and, sometimes, death.

Most often develops as secondary hypertension to diseases such as CKD and hyperthyroidism.

Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Information for Cat Owners

Always provide the Client Information Sheet with each prescription and review it with the cat owner. Advise cat owners that adverse reactions can occur with use of SEMINTRA. The most common adverse reactions reported during the field studies included vomiting, diarrhea, lethargy, weight loss, anemia and dehydration.

Contraindications

Do not use in cats with a hypersensitivity to telmisartan.

Human Warnings

Not for human use. Keep out of reach of children.

SEMINTRA is an angiotensin II antagonist/angiotensin receptor blocker (ARB). Pregnant women should avoid contact with SEMINTRA because substances that act on the renin-angiotensin-aldosterone system (RAAS) such as angiotensin receptor blockers (ARBs) can cause fetal and neonatal morbidity and death during pregnancy in humans.

Precautions

SEMINTRA has not been evaluated in cats with systolic blood pressure >200 mm Hg.

SEMINTRA can cause mild anemia or nonregenerative anemia. Cats should be monitored for anemia when initiating treatment with SEMINTRA.

SEMINTRA may cause inappetence and weight loss in some cats. Cats should be monitored for weight loss when initiating treatment with SEMINTRA. Use with caution in cats with a history of vomiting, inappetence or weight loss.

The safe use of SEMINTRA in cats with hepatic disease has not been evaluated. SEMINTRA is metabolized by the liver.

The safe use of SEMINTRA has not been evaluated in cats less than 9 months of age.

The safe use of SEMINTRA has not been evaluated in cats that are pregnant, lactating, or intended for breeding. See Human Warnings.

The safe use with other anti-hypertensive medications has not been evaluated.

Storage

Store at or below 25°C (77°F) with excursions permitted up to 40°C (104°F). Once the bottle is opened, use the contents within six months.