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Description:
TRIFEXIS (spinosad and milbemycin oxime) is available in
five sizes for oral administration to dogs and puppies according to
their weight. Each chewable flavored tablet is formulated to provide a
minimum spinosad dose of 13.5 mg/lb (30 mg/kg) and a minimum milbemycin
oxime dose of 0.2 mg/lb (0.5 mg/kg). Spinosad is a member of the
spinosyns class of insecticides, which are non-antibacterial tetracyclic
macrolides. Spinosad contains two major factors, spinosyn A and
spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa. Spinosyn A and spinosyn D have the chemical compositions C41H65NO10 and C42H67NO10, respectively. Milbemycin oxime is a macrocyclic lactone anthelmintic, containing two major factors, A3 and A4 of milbemycin oxime. The approximate ratio of A3:A4 is 20:80. Milbemycin A4 5-oxime has the chemical composition of C32H45NO7 and milbemycin A3 5-oxime has the chemical composition of C31H43NO7.
Indications:
TRIFEXIS is indicated for the prevention of heartworm disease (Dirofilaria immitis). TRIFEXIS kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
Dosage and Administration:
TRIFEXIS is given orally, once a month at the minimum
dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg)
milbemycin oxime body weight. For heartworm prevention, give once
monthly for at least 3 months after exposure to mosquitoes (see EFFECTIVENESS).
Dosage Schedule:
Body Weight |
Spinosad Per Tablet (mg) |
Milbemycin oxime Per Tablet (mg) |
Tablets Administered |
5 to 10 lbs |
140 |
2.3 |
One |
10.1 to 20 lbs |
270 |
4.5 |
One |
20.1 to 40 lbs |
560 |
9.3 |
One |
40.1 to 60 lbs |
810 |
13.5 |
One |
60.1 to 120 lbs |
1620 |
27 |
One |
Over 120 lbs |
Administer the appropriate combination of tablets |
Administer TRIFEXIS with food for maximum effectiveness. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of TRIFEXIS with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations. If vomiting occurs within an hour of administration, redose with another full dose.
Heartworm Prevention:
TRIFEXIS should be administered at monthly intervals beginning within 1 month of the dog’s first seasonal exposure and continuing until at least 3 months after the dog’s last seasonal exposure to mosquitoes (see EFFECTIVENESS). TRIFEXIS may be administered year round without interruption. When replacing another heartworm preventative product, the first dose of TRIFEXIS should be given within a month of the last dose of the former medication.
Flea Treatment and Prevention:
Treatment with TRIFEXIS may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with TRIFEXIS should continue the entire year without interruption.
To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.
Intestinal Nematode Treatment and Control:
TRIFEXIS also provides treatment and control of roundworms (T. canis, T. leonina), hookworms (A. caninum) and whipworms (T. vulpis). Dogs may be exposed to and can become infected with roundworms, whipworms and hookworms throughout the year, regardless of season or climate. Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.
View full product label for complete safety information.
Description:
TRIFEXIS (spinosad and milbemycin oxime) is available in
five sizes for oral administration to dogs and puppies according to
their weight. Each chewable flavored tablet is formulated to provide a
minimum spinosad dose of 13.5 mg/lb (30 mg/kg) and a minimum milbemycin
oxime dose of 0.2 mg/lb (0.5 mg/kg). Spinosad is a member of the
spinosyns class of insecticides, which are non-antibacterial tetracyclic
macrolides. Spinosad contains two major factors, spinosyn A and
spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa. Spinosyn A and spinosyn D have the chemical compositions C41H65NO10 and C42H67NO10, respectively. Milbemycin oxime is a macrocyclic lactone anthelmintic, containing two major factors, A3 and A4 of milbemycin oxime. The approximate ratio of A3:A4 is 20:80. Milbemycin A4 5-oxime has the chemical composition of C32H45NO7 and milbemycin A3 5-oxime has the chemical composition of C31H43NO7.
Indications:
TRIFEXIS is indicated for the prevention of heartworm disease (Dirofilaria immitis). TRIFEXIS kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
Dosage and Administration:
TRIFEXIS is given orally, once a month at the minimum
dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg)
milbemycin oxime body weight. For heartworm prevention, give once
monthly for at least 3 months after exposure to mosquitoes (see EFFECTIVENESS).
Dosage Schedule:
Body Weight |
Spinosad Per Tablet (mg) |
Milbemycin oxime Per Tablet (mg) |
Tablets Administered |
5 to 10 lbs |
140 |
2.3 |
One |
10.1 to 20 lbs |
270 |
4.5 |
One |
20.1 to 40 lbs |
560 |
9.3 |
One |
40.1 to 60 lbs |
810 |
13.5 |
One |
60.1 to 120 lbs |
1620 |
27 |
One |
Over 120 lbs |
Administer the appropriate combination of tablets |
Administer TRIFEXIS with food for maximum effectiveness. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of TRIFEXIS with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations. If vomiting occurs within an hour of administration, redose with another full dose.
Heartworm Prevention:
TRIFEXIS should be administered at monthly intervals beginning within 1 month of the dog’s first seasonal exposure and continuing until at least 3 months after the dog’s last seasonal exposure to mosquitoes (see EFFECTIVENESS). TRIFEXIS may be administered year round without interruption. When replacing another heartworm preventative product, the first dose of TRIFEXIS should be given within a month of the last dose of the former medication.
Flea Treatment and Prevention:
Treatment with TRIFEXIS may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with TRIFEXIS should continue the entire year without interruption.
To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.
Intestinal Nematode Treatment and Control:
TRIFEXIS also provides treatment and control of roundworms (T. canis, T. leonina), hookworms (A. caninum) and whipworms (T. vulpis). Dogs may be exposed to and can become infected with roundworms, whipworms and hookworms throughout the year, regardless of season or climate. Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.