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Spironolactone & Hydrochlorothiazide Tablets

Spironolactone & Hydrochlorothiazide Tablets
25mg/25mg, 100 count - tablets
SKU : 32208_-RX
Price: $129.95
Price: $129.95
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Veterinarian Prescription (Rx) Required 
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  • Used as a diuretic or for the treatment of heart failure
  • Helps the body retain the potassium that is sometimes lost in large amounts when using other diuretics
  • Available Size
    • 25mg/25mg, 100 count
How to Order Prescriptions


Spironolactone, an ingredient of spironolactone and hydrochlorothiazide, has been shown to be a tumorigenic in chronic toxicity studies in rats (see PRECAUTIONS section). Spironolactone and hydrochlorothiazide should be used only in those conditions described below. Unnecessary use of this drug should be avoided.
  • Spironolactone plus Hydrochlorothiazide.
  • Spironolactone: 25 mg
  • Hydrochlorothiazide: 25 mg


Spironolactone and hydrochlorothiazide tablets are contraindicated in patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, or hyperkalemia, and in patients who are allergic to thiazide diuretics or to other sulfonamide-derived drugs. Spironolactone and hydrochlorothiazide may also be contraindicated in acute or severe hepatic failure.

Dosage and Administration

Give Spironolactone with food to lessen stomach upset. Keep plenty of water available for your pet.

Spironolactone is a water pill (potassium-sparing diuretic) available by prescription that is used to treat edema, high blood pressure, potassium deficiency, and hyperaldosteronism.

Spironolactone is used to reduce the amount of fluid in the body without also causing loss of potassium.

Pet Weight  Dosage 
       Dogs         All Weights       The usual dose in dogs and cats is 0.5 mg - 1 mg per pound of body weight every 12 hours
Cats  All Weights        The usual dose in dogs and cats is 0.5 mg - 1 mg per pound of body weight every 12 hours


Spironolactone Hydrochlorothiazide should not be used in pets with hyperkalemia (high potassium levels), Addison's disease, kidney failure, severe renal failure or significant renal impairment. It should be used cautiously in animals with hepatic (liver) disease, but is often used to treat ascites (accumulation of fluid in the peritoneal cavity, which causes abdominal swelling).

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.

Possible Side Effects

Please contact your veterinarian if you notice any of the following reactions: dehydration with excessive thirst and decreased urine production, or electrolyte imbalances, possibly with weakness, lethargy, restlessness, stumbling, dizziness, muscle pain or cramping, lack of energy, vomiting and diarrhea.