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Heartgard Plus for Dogs

Heartgard Plus for Dogs Chewables
Up to 25 lbs, 6 Month - Blue (6 Chews)
Up to 25 lbs, 12 Month - Blue (12 Chews)
26-50 lbs, 6 Month - Green (6 Chews)
26-50 lbs, 12 Month - Green (12 Chews)
51-100 lbs, 6 Month - Brown (6 Chews)
51-100 lbs, 12 Month - Brown (12 Chews)
SKU : 1110_-RX
Price: $51.09
Price: $51.09
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Prevents heartworm disease in dogs

Veterinarian Prescription (Rx) Required
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  • (ivermectin / pyrantel)
  • Beef-Flavored Chewables
  • Prevents heartworm disease
  • Treats and controls ascarid and hookworm infections
  • For Use in Dogs and Puppies 6 Weeks of Age or Older

See Tri-Heart Plus as an alternative to this product.

*Manufacturer restricts additional discounts on this item unless explicitly specified

How to Order Prescriptions


Heartgard PLUS is a monthly pet medication for the prevention of heartworm disease. Heartgard PLUS is 100% effective against heartworms; and it controls roundworms and hookworms. Heartgard PLUS treats and controls more effectively than the next leading brand and is veterinarian recommended. Heartgard PLUS is approved for puppies and kittens as young as 6 weeks of age. Help your pet by ordering Heartgard PLUS today.

    • Prevents heartworm disease
    • Prevents development of adult stage heartworms
    • Treats and controls roundworms
    • Treats and controls hookworms
    • Beef flavor chewable
    • For dogs only


    • Highly effective in preventing heartworms
    • A convenient and tasty chewable for easy administration
    • Delicious beef flavor that most dogs will eat

How it works

Heartgard prevents heartworm disease by eliminating the tissue stage of heartworm larvae for a month after infection.

Dosage & Administration

Give Heartgard Plus exactly as directed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Heartgard Plus chewable tablets must be chewed. They should not be swallowed whole. Use with caution, Collies and other herding dog breeds have been known to have adverse reactions to invermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If the animal is off Heartgard Plus for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Heartgard Plus at room temperature. Do not remove the tablet from its wrapper until ready to give the medicine. Keep this medication away from children and pets. In addition, Heartgard Plus has shown a wide margin of safety at the recommended dose level in dogs including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks.

View Heartgard Plus Drug Facts Sheet.


    • Give Heartgard Plus Chewables once a month on the same day of each month year round.
    • Heartgard Plus Chewables are for dogs only. Do not give to cats.
    • Heartgard Plus Chewables should not be swallowed whole.
    • Chewables may be broken and fed to dogs as pieces, or crumbled and mixed with food.
    • Watch dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.


Do not remove chewable from its wrapper until ready to give to pet.
Pet Weight  mg Dosage
(6 weeks of age and older)
Up to 25 lbs  57mg Give 1 chewable every month (Blue Box)
  26-50 lbs  114mg Give 1 chewable every month (Green Box)
  51-100 lbs  227mg Give 1 chewable every month (Brown Box)
  Over 100 lbs   Give combination of chewables based on weight
Cats: X   X
Horses: X   X

 Store this product at room temperature. Keep out of reach of children.

What happens if I miss giving a dose?

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What happens if I overdose the pet?

Seek emergency veterinary medical treatment. Symptoms of overdose may include vomiting, diarrhea and incoordination in dogs.

What should I avoid while giving Heartgard Plus?

Because humans can contract hookworm from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on the pet and in the household and to not feed the pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.

What are the possible side effects of Heartgard Plus?

Side effects of Heartgard Plus are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, and loss of body weight and death.

What other drugs will affect Heartgard Plus?

Do not give Heartgard Plus to your pet if already taking another heartworm medication.


Can cause sensitivities in herding dog breeds. It is important that you give your pet this preventative every month. If you miss more than two monthly doses, we recommend calling your vet before continuing the medication. Also, note that side effects are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight, and death. Side effects in cats include agitation, loss of appetite, staggering, dilated pupils, tremors, blindness and disorientation.
RX required for this item.
Click here for our full Prescription Policy and Form

by Merial

Heartgard Plus Chews
  • Heartworm Disease Prevention
  • Only Heartgard Plus Chews come in a real-beef chewable that dogs love

HEARTGARD Plus for dogs helps prevent canine heartworm disease, and treats and controls roundworms and hookworms, too. Available in 3 different sizes in a 6-pack or 12-pack supply.

  • The veterinarian's #1 choice for heartworm disease prevention in dogs.
  • Used monthly as directed can help prevent heartworm infection in your dog – and can help your dog avoid the risk, stress, and long periods of confinement that go along with treatment for canine heartworm disease.
  • Made with real beef – dogs love the taste.
  • Convenient, easy-to-give Chewable that most dogs will eat right out of your hand.
  • Available in three dosage strengths for dogs of different weights. Your veterinarian will select the dosage that's right for your dog.
  • Has a wide margin of safety for dogs of all breeds and sizes when used as directed. It is approved for puppies as young as 6 weeks, pregnant or breeding female dogs, and stud dogs.
  • HEARTGARD for dogs: Easy to Give. Protection to Live.
  • HEARTGARD® Plus should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight