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Revolt (selamectin) for Cats

Revolt (selamectin) for Cats
Kittens Up to 5 lbs, 3 Doses - Mauve
Cats 5.1 to 15 lbs, 3 Doses - Blue
Cats 5.1 to 15 lbs, 6 Doses - Blue
Cats 15.1 to 22 lbs, 3 Doses - Grey
Cats 15.1 to 22 lbs, 6 Doses - Grey
SKU : 21369_-RX
Price: $29.74
Price: $29.74
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Monthly control of heartworm, fleas, ear mites in dogs and cats, monthly control of American dog tick and sarcoptic manage in dogs, and treatment of roundworms and hookworms in cats.

Veterinarian Prescription (Rx) Required
Free Shipping on orders over $75
  • Available Sizes
    • Kittens Up to 5 lbs: 3 doses
    • Cats 5.1-15 lbs: 3 doses, 6 doses
    • Cats 15.1-22 lbs: 3 doses, 6 doses
*Manufacturer restricts additional discounts on this item unless explicitly specified. 


Revolt™ (selamectin) Topical Parasiticide is a highly affordable, once-a-month prevention answer for  heartworms, fleas and a host of other problematic parasites. Revolt™ offers the same active ingredient  and mode of action as the pioneer product, Revolution® Topical Solution, but at greatly reduced pricing.


    • Revolt™ is Specifically Designed to Offer a Full-Line Comparison to Revolution®
    • Best Pricing, Always
    • Safe & Secure Supply Chain – Revolt™ is Manufactured and Packaged in the USA
    • Ease of Administration – Revolt’s™ easy twist-to-apply design simplifies the application process, eliminating the need to remove the cap
    • Revolt™ – Packaged for Ease of Use – Like all Aurora Pharmaceutical products, improved packaging design is always a high priority. Revolt™ packaging is no exception.
    • Innovative tube design ensures stability
    • Revolt’s™ individual blister pack makes removing the tube easy – no tools needed to break the package seal
    • Product color coding matches pioneer for ease of conversion
    • Full line, weight-specific products assure your clients are applying the exact protective dose of selamectin each time

Revolt™ Defends Against

  • FLEAS (Ctenocephalides felis)
  • EAR MITES (Otodectes cynotis)
  • ROUNDWORMS (Toxocara cati)
  • HOOKWORMS (Ancylostoma tubaeforme)
  • HEARTWORM (Dirofilaria immitis)
  • AMERICAN DOG TICK (Dermacentor variabilis)

Flea Control in Dogs and Cats

For the prevention and control of flea infestations, Revolt should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. In controlled laboratory studies >98% of fleas were killed within 36 hours. Results of clinical field studies using selamectin monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with selamectin, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment. If the dog or cat is already infested with fleas when the first dose of Revolt is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. However, an environmental infestation of fleas may persist for a short time after beginning treatment with Revolt because of the emergence of adult fleas from pupae. 

Heartworm Prevention in Dogs and Cats

For the prevention of heartworm disease, Revolt must be administered on a monthly basis. Revolt may be administered year-round or at least within one month after the animal’s first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of Revolt and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Revolt must be given within a month of the last dose of the former medication. Selamectin, the active ingredient in Revolt, is a macrocyclic lactone compound. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using Revolt beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at >8 weeks of age), or gaps of >2 months in the administration of Revolt during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of Revolt may be harboring pre-patent infections at the time Revolt was started. Testing such animals 3–4 months after initiation of Revolt would be necessary to confirm their negative heartworm status. At the discretion of the veterinarian, cats ≥ 6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with Revolt. Cats already infected with adult heartworms can be given Revolt monthly to prevent further infections. 

Ear Mite Treatment in Dogs and Cats

For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Revolt should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Revolt will control any subsequent ear mite infestations. In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the second dose. Cleansing of the infested ears is recommended to remove the debris. 

Nematode Treatment in Cats

For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections, Revolt should be applied once as a single topical dose.


The recommended minimum dose is 2.7 mg  selamectin per pound (6 mg/kg) of body weight. Administer the entire contents of a single dose tube (or the appropriate combination of tubes for cats over 22 lbs. and dogs over 130 lbs.) of Revolt™ topically in accordance with the following table.


Package Color

Weight (lbs)

Mg per tube

Potency (mg/mL)

Admin. Volume (mL)

Revolt™ Kitten


Up to 5

15 mg



Revolt™ Cat



45 mg



Revolt™ Cat



60 mg




1.  Remove the Revolt™ tube from its  protective package.

2.  While holding the tube in an upright position, twist the cap to break the seal. The cap will remain on the tube.

3.  Part the hair on the back of the  animal at the base of the neck,  in front of the shoulder blades,  until the skin is visible.

4.  Apply the tip of the Revolt™ tube  directly to the skin. Squeeze the tube firmly 3 to 4 times in one spot until empty. Keep the tube compressed on the final squeeze to avoid drawing liquid back into tube. Avoid contact between Revolt™ and your fingers.

5.  While keeping tube squeezed, drag it away from liquid and lift up to remove.

6. Ensure tube is empty.

Helpful Tips

    •  Do not massage Revolt™ into the skin.
    •  Do not apply when the haircoat is wet.
    •  Do not apply to broken skin – Revolt™ contains alcohol.
    • Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the site in some animals. These effects are usually temporary and do not affect the safety or effectiveness of the product.


Revolt kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolt is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.


  • Not for human use. Keep out of the reach of children.
  • In humans, Revolt may be irritating to skin and eyes.
Reactions such as hives, itching and skin redness have been reported in humans in rare instances. Individuals with known hypersensitivity to Revolt should use the product with caution or consult a health care professional. Revolt contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water. In case of ingestion by a human, contact a physician immediately. The safety data sheet (SDS) provides more detailed occupational safety information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the SDS, contact Aurora Pharmaceutical at 1-888-215-1256 or For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at Flammable - Keep away from heat, sparks, open flames or other sources of ignition. Do not use in sick, debilitated or underweight animals (see SAFETY).


Prior to administration of Revolt, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Revolt is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, Revolt is not effective for microfilariae clearance. Hypersensitivity reactions have not been observed in dogs with patent heartworm infections administered three times the recommended dose of selamectin. Higher doses were not tested.

Storage Conditions

Store below 30°C (86°F). 

How Supplied

Available in eight separate dose strengths for dogs and cats of different weights (see DOSAGE). Revolt for puppies and kittens is available in cartons containing 3 single dose tubes. Revolt for cats and dogs is available in cartons containing 3 or 6 single dose tubes.