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Advantage MULTI for Cats

MULTI Advantage for Cats

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MULTI Advantage for Cats

5.1-9 lbs/6mth - 6 pack (orange) Free Shipping
5.1-9 lbs/12mth - 12 Month (orange) Free Shipping
9.1-18 lbs/6mth - 6 pack (purple) Free Shipping
9.1-18 lbs/12mth - 12 Month (purple) Free Shipping
SKU: 5527-RX
Price: $76.95

Veterinarian Prescription (Rx) Required
Free Shipping
  • Once-A-Month Topical Solution for Cats (imidacloprid +moxidectin)
  • Prevention of heartworm disease
  • Kills adult fleas and is indicated for the treatment of flea infestations
  • Treatment and control of ear mite infestations, hookworms and roundworms
RX required for this item.
Click here for our full Prescription Policy and Form

by Bayer

Advantage Multi® for Cats
(imidacloprid + moxidectin) Topical Solution

New prescription-only Advantage Multi for Cats combines the proven-effective flea control of Advantage®, which has been trusted by veterinarians and their clients for more than 10 years, with a 100-percent effective preventative for heartworm disease and highly effective treatment and control of intestinal nematodes (hookworms and roundworms) all in one convenient, monthly topical solution. Advantage Multi for Cats also treats and controls ear mite infestations.

Two active ingredients for broad coverage:

  1. Moxidectin acts systemically to target endoparasites. It is absorbed for heartworm prevention and intestinal nematode control for the whole month.
  2. Imidacloprid acts topically to target ectoparasites. It is spread across the skin surface, and into the superficial lipid level for month-long flea kill.
Why Advantage MULTI?
  • 100 percent effective at preventing heartworm disease caused by Dirofilaria immitis.
  • Up to 100 percent effective treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae) and roundworm infections caused by Toxocara cati (adults and fourth stage larvae).
  • Proven effective (up to 99.6 percent) treatment and control of ear mite (Otodectes cynotis) infestations.
  • Safe and effective, when used topically as directed, for cats and kittens that are at least nine weeks of age and that weigh at least two pounds.
  • Once-a-month, ready-to-use topical solution packaged in six, single-dose applicator tubes available for cats weighing 5.1 to 9 pounds and 9.1 to 18 pounds.

See Product Label tab

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Advantage Multi® for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight.

Imidacloprid is a chloronicotinyl nitroguanidine insecticide. The chemical name of imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidinimine. Moxidectin is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus. The chemical name of moxidectin is [6R, 23E, 25S(E)]-5-O- Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino) milbemycin B.


Advantage Multi for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. Advantage Multi for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. Advantage Multi for Cats is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites:

Intestinal Parasite

Intestinal Stage


Immature Adult

Fourth Stage Larvae

Hookworm Species

Ancylostoma tubaeforme




Roundworm Species

Toxocara cati





The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Do not apply to irritated skin.

1. Remove one dose applicator tube (tube) from the package. As specified in the following table, administer the entire contents of the Advantage Multi® for Cats tube that correctly corresponds with the body weight of the cat.

Cat (lbs.)

Advantage Multi for Cats

Volume (mL)

Imidacloprid (mg)

Moxidectin (mg)


Advantage Multi 5





Advantage Multi 9





Advantage Multi 18




* Cats over 18 lbs. should be treated with the appropriate combination of Advantage Multi for Cats tubes.

2. While holding the tube in an upright position, remove the cap from the tube.

3. Turn the cap over and push the other end of cap onto the tip of the tube.

4. Twist the cap to break the seal and then remove cap from the tube.

5. Part the hair on the back of the cat’s neck at the base of the head, until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift tube away from skin before releasing pressure on tube.

Do not get this product in the cat’s mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animals separated to prevent licking of the application site.

Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. This is temporary and does not affect the safety and effectiveness of the product.

Heartworm Prevention: For prevention of heartworm disease, Advantage Multi for Cats should be administered at one-month intervals. Advantage Multi for Cats may be administered year-around or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Cats immediately and resume the monthly dosing schedule. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Cats should be given within one month of the last dose of the former medication. At the discretion of the veterinarian, cats older than 6 months of age may be tested to determine the presence of existing heartworm infection before treatment with Advantage Multi for Cats (See ADVERSE REACTIONS - Foreign Market Experience).

Flea Treatment: For the treatment of flea infestations, Advantage Multi for Cats should be administered at one-month intervals. If the cat is already infested with fleas when the first dose of Advantage Multi for Cats is administered, adult fleas on the cat will be killed. However, re-infestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Cats treated with imidacloprid, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the cat.

Ear Mite Treatment: For the treatment of ear mites (Otodectes cynotis), Advantage Multi for Cats should be administered once as a single topical dose. Monthly use of Advantage Multi for Cats will control any subsequent ear mite infestations.

Intestinal Nematode Treatment: For the treatment and control of intestinal hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara cati (adults and fourth stage larvae), Advantage Multi for Cats should be administered once as a single topical dose.



Applications Per Package


3 x 0.23 mL tubes


6 x 0.4 mL tubes


6 x 0.8 mL tubes

Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328 and 6,001,858.

08944663, R.3

February 2009



NADA # 141-254, Approved by FDA

© 2009 Bayer HealthCare LLC

Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer.

Made in Germany.

Bayer HealthCare LLC, Animal Health Division, P.O. Box 390, Shawnee Mission, Kansas 66201 U.S.A.

Regulations for product use are established by country. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. Before using or dispensing any product, read and carefully observe the label directions.

We are unable to ship prescriptions into Arkansas, Louisiana, Georgia, Mississippi,
and North Carolina
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