GastroGard Paste
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- Oral Paste for Equine Ulcers (omeprazole)
- Improves and Heals Gastric Ulcers
- Prevents Gastric Ulcer Recurrence
- Once-a-Day Dosing
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by Merial
Uses
GastroGard for Horses -2.28gm tube is an oral paste used for the treatment and prevention of recurrence of equine gastric ulcers.
How GastroGard Paste Works
Utilizing Omeprazole, GastroGard pastes provides superior acid suppression because it most effectively shuts down acid production in the stomach, giving the ulcer time to heal. The cells of the stomach mucosa contain several acid-stimulating receptors, and when these receptors are activated they switch on the H+,K+ ATPase acid pump (an enzyme system) to secrete acid into the stomach. Omeprazole inhibits the acid pump, so when receptors are activated the acid pump does not initiate acid secretion. Omeprazole is the only medication approved for use in horses that acts directly on the acid pump, preventing acid secretion no matter what receptor is activated.
Omeprazole was the first acid pump inhibitor to be approved for use in humans, and is now the first and only acid pump inhibitor approved for the treatment of stomach ulcers in horses.6 In a pharmacokinetic study involving thirteen healthy, mixed-breed horses (8 female, 5 male) receiving multiple doses of omeprazole GastroGard paste (1.8 mg/lb once daily for 15 days) in either a fed or fasted state, there was no evidence of drug accumulation in the plasma when comparing the extent of systemic exposure (AUC-0-infinity). When comparing the individual bioavailability data (AUC-0-infinity, Cmax, and Tmax measurements) across the study days (doses 1 and 15 in fed animals), there was great inter- and intrasubject variability in the rate and extent of product absorption.
Active Ingredient: Omeprazole
Dosage
The minimum recommended dosage is 1.8 mg/lb per day (4.0 mg/kg). Weight markings on the syringe plunger can be used for dosing; the contents of one syringe will dose a 1,250 lb horse.
GASTROGARD for Horses should be administered orally once-a-day for 4 weeks (28 days).
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