Sentinel for Dogs

Sentinel for Dogs
Dogs 2 to 10 lbs (Brown), 6 Pack -  
Dogs 11 to 25 lbs (Green), 6 Pack - 
Dogs 26 to 50 lbs (Yellow), 6 Pack - 
Dogs 51 to 100 lbs (White), 6 Pack - 
SKU : 1150_-RX
Price: $48.99
Price: $48.99
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  • (milbemycin oxime + lufenuron)
  • Prevents heartworm disease
  • Prevents and controls flea populations
  • Controls adult hookworm infections
  • Removes and controls adult roundworm and whipworm infections
  • Recommended for Dogs and Puppies 4 weeks of age or older
Manufacturer restricts additional discounts on this item unless explicitly specified. 
How to Order Prescriptions

Description

Sentinel (milbemycin oxime - lufenuron)
The palatable once-a-month prescription tablet that prevents heartworm disease and flea populations in dogs and puppies. SENTINEL® (milbemycin oxime/lufenuron) Flavor Tabs® also control flea populations and adult hookworms, and remove and control adult roundworm and whipworm infections in dogs and puppies.
 
SENTINEL is indicated for the prevention of heartworm disease (Dirofilaria immitis). SENTINEL kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canisand Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.

Things every pet owner should know about fleas

    • Fleas can infest your home even in the cold winter months.
    • Fleas picked up outside the home can lead to infestations.
    • All pets in a home should be on flea prevention, even if they spend all their time indoors.

Key Benefits

    • Prevents heartworm disease
    • Comes in palatable beef flavored tabs
    • Easy to administer just once a month
    • Controls flea population
    • Controls hookworms
    • Removes and controls roundworms
    • Removes and controls whipworms

How It Works

Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm infestations. Lufenuron, the other active ingredient, is an insect development inhibitor that breaks the flea life cycle by inhibiting egg development. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle.

Ingredients

Active Ingredient (per tablet)  Milbemycin Oxime  Lufenuron
 Sentinel Brown  2.3 mg   46 mg
 Sentinel Green  5.75 mg  115 mg
 Sentinel Yellow  11.5 mg   230 mg
 Sentinel White  23 mg  460 mg

 

Directions

Sentinel Flavor Tabs are given orally, once a month, at the recommended minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime and 4.55 mg/lb (10 mg/kg) lufenuron.

Dogs over 100 lbs are provided the appropriate combination of tablets.

Administration

To ensure adequate absorption, always administer Sentinel Flavor Tabs to dogs immediately after or in conjuction with a normal meal.

Sentinel Flavor Tabs are palatable and most dogs will consume the tablet when offered by the owner. As an alternative to direct dosing, the tablets can be hidden in food. Be certain the dog consumes the entire tablet or tablets. Administer Sentinel Flavor Tabs to dogs immediately after or in conjunction with a normal meal. Food is essential for adequate absorption of lufenuron. Watch the dog closely following administration to be sure the entire dose has been consumed. If it is not entirely consumed, redose with the full recommended dose as soon as possible.

 

Recommended Dosage Schedule

Body Weight   Milbemycin Oxime Per Tablet    Lufenuron Per Tablet   Monthly Dosage
 2 to 10 lbs  2.3 mg  46 mg   1 (Brown)
 11 to 25 lbs  5.75 mg  115 mg  1 (Green)
 26 to 50 lbs   11.5 mg  230 mg  1 (Yellow)
 51 to 100 lbs   23 mg  460 mg  1 (White)
 Over 100 lbs    Give combination of Flavor Tabs based on weight

Sentinel Flavor Tabs must be administered monthly, preferably on the same date each month. Treatment with Sentinel Flavor Tabs may begin at any time of year. In geographic areas where mosquitoes and fleas are seasonal, the treatment schedule should begin one month prior to the expected onset and should continue until the end of "mosquito and flea season." In areas with year-round infestations, treatment should continue through the entire year without interruption.

Adverse Reactions

The following adverse reactions have been reported in dogs after giving milbemycin oxime or lufenuron: vomiting, depression/lethargy, pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia, convulsions, hypersalivation, and weakness.

To report suspected adverse drug events, contact Virbac at 1-800-338-3659. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth.

Mode of Action

Milbemycin oxime, one active ingredient in Sentinel Flavor Tabs, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm (Ancylostoma caninum), roundworm (Toxocara canis and Toxascaris leonina) and whipworm (Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule.

Lufenuron, the other active ingredient in Sentinel Flavor Tabs, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. Lufenuron's mode of action is interference with chitin synthesis, polymerization and deposition. Lufenuron has no effect on the adult flea. After biting a lufenuron-treated dog, the female flea ingests a blood meal containing lufenuron which is subsequently deposited in her eggs. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. (See Efficacy).

Indications

Sentinel Flavor Tabs are indicated for use in dogs and puppies, four weeks of age and older, and two pounds body weight or greater. Sentinel Flavor Tabs are also indicated for the prevention of heartworm disease caused by Dirofilaria immitis for the prevention and control of flea populations, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult Toxocara canis and Toxascaris leonina (roundworm) and Trichuris vulpis (whipworm) infections.

Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. Concurrent use of an adulticide product may be necessary for adequate control of adult fleas.

Without concurrent use of an adulticide, adequate flea control may not be achieved in dogs that have repeated exposure to flea infested animals or environments.

Caution

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Warnings

Not for human use. Keep this and all drugs out of the reach of children.

Precautions

Do not use in puppies less than four weeks of age and less than two pounds of body weight. Prior to administration of Sentinel Flavor Tabs, dogs should be tested for existing heartworm infections. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with Sentinel Flavor Tabs. Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy have been noted in some treated dogs carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.

Sentinel Flavor Tabs immediately break the flea life cycle by inhibiting egg development. However, preexisting flea populations may continue to develop and emerge after treatment with Sentinel Flavor Tabs has begun. Based on results of clinical studies, this emergence generally occurs during the first 30-60 days. Therefore, noticeable control may not be observed until several weeks after dosing when a preexisting infestation is present. Cooler geographic areas may have longer lag periods due to a prolonged flea life cycle. The concurrent use of an approved adulticide may be employed depending on the severity of the infestation.

If a Sentinel Flavor Tabs-treated dog comes in contact with a flea-infested environment, adult fleas may infest the treated animal. These adult fleas are unable to produce viable offspring. The temporary use of an adulticide product may be necessary to kill these adult fleas.

 

Efficacy: Milbemycin Oxime

Milbemycin oxime provided complete protection against heartworm infection in both controlled laboratory and clinical trials.

In laboratory studies, a single dose of milbemycin oxime at 0.5 mg/kg was effective in removing roundworm, hookworm and whipworm. In well-controlled clinical trials, milbemycin oxime was also effective in removing roundworms and whipworms and in controlling hookworms.

Efficacy: Lufenuron

Lufenuron provided 99% control of flea egg development for 32 days following a single dose of lufenuron at 10 mg/ kg in studies using experimental flea infestations. In well-controlled clinical trials, when treatment with lufenuron tablets was initiated prior to the flea season, mean flea counts were lower in lufenuron-treated dogs versus placebo-treated dogs. After 6 monthly treatments, the mean number of fleas on lufenuron-treated dogs was approximately 4 compared to 230 on placebo-treated dogs.

When treatment was initiated during the flea season, lufenuron tablets were effective in controlling flea infestations on dogs that completed the study. The mean flea count per lufenuron-treated dog was approximately 74 prior to treatment but had decreased to 4 after six monthly doses of lufenuron. A topical adulticide was used in the first eight weeks of the study to kill the pre-existing adult fleas.

 

Safety: Milbemycin Oxime

Milbemycin oxime has been tested safely in over 75 different breeds of dogs, including collies, pregnant females, breeding males and females, and puppies over two weeks of age. In well-controlled clinical field studies 786 dogs completed treatment with milbemycin oxime. Milbemycin oxime was used safely in animals receiving frequently used veterinary products such as vaccines, anthelmintics, antibiotics, steroids, flea collars, shampoos and dips.

Two studies in heartworm-infected dogs were conducted which demonstrated mild, transient hypersensitivity reactions in treated dogs with high microfilaremia counts (see Precautions for reactions observed). Safety studies in pregnant dogs demonstrated that high doses (1.5 mg/kg = 3X)of milbemycin oxime given in an exaggerated dosing regimen (daily from mating through weaning), resulted in measurable concentrations of the drug in milk. Puppies nursing these females which received exaggerated dosing regimens demonstrated milbemycin-related effects. These effects were directly attributable to the exaggerated experimental dosing regimen. The product is normally intended for once-a-month administration only. Subsequent studies included using 3X daily from mating to one week before weaning and demonstrated no effects on the pregnant females or their litters. A second study where pregnant females were dosed once at 3X the monthly use rate either before, on the day of or shortly after whelping resulted in no effects on the puppies.

Some nursing puppies, at 2, 4, and 6 weeks of age, given greatly exaggerated oral doses of milbemycin oxime (9.6 mg/ kg = 19X) exhibited signs typified by tremors, vocalization and ataxia. These effects were all transient and puppies returned to normal within 24 to 48 hours. No effects were observed in puppies given the recommended dose of milbemycin oxime (0.5 mg/ kg). This product has not been tested in dogs less than 2.2 pounds in body weight.

A rising-dose safety study conducted in rough-coated collies manifested a clinical reaction consisting of ataxia, pyrexia and periodic recumbency in one of fourteen dogs treated with milbemycin oxime at 12.5 mg/kg (25X monthly use rate). Prior to receiving the 12.5 mg/kg dose (25X monthly use rate) on day 56 of the study, all animals had undergone an exaggerated dosing regimen consisting of 2.5 mg/kg milbemycin oxime (5X monthly use rate) on day 0, followed by 5.0 mg/kg (10X monthly use rate) on day 14 and 10.0 mg/kg (20X monthly use rate) on day 32. No adverse reactions were observed in any of the collies treated with this regimen up through the 10.0 mg/kg (20X monthly use rate) dose.

Safety: Lufenuron

Lufenuron tablets have been used and tested safely in over forty breeds of dogs, including pregnant females, breeding males and puppies over six weeks of age. In well-controlled clinical trials, 151 dogs completed treatment with lufenuron tablets. Lufenuron tablets were used safely in animals receiving frequently used veterinary products such as vaccines, anthelmintics, antibiotics and steroids. In a ten-month study, doses up to 10X the recommended dose rate of 10 mg/kg caused no overt toxicity. A single dose of 200 mg/kg (20X the recommended dose rate) had no marked effect on adult dogs, but caused decreased activity and appetite in eight week old puppies. Mean body weights of male and female puppies were higher in treated versus control group at the end of the study. In specifically designed target animal safety studies, lufenuron tablets were tested with concurrent administration of flea adulticides containing carbaryl, permethrin, chlorpyriphos and cythioate. No toxicity resulted from these combinations. Lufenuron tablets did not cause cholinesterase inhibition nor did they enhance cholinesterase inhibition caused by exposure to organophosphates.

Four reproductive safety studies were conducted in breeding dogs with lufenuron tablets: two laboratory and two well- controlled clinical studies. In one of the laboratory studies, where lufenuron was administered to beagle dogs at doses equivalent to 90X (3X daily) the monthly recommended dose of 10 mg/kg, the ratio of gravid females to females mated was 8/8 or 100% in the control group and 6/9 or 67% in the lufenuron-treated group. The mean number of pups per litter was two animals higher in the treated versus control groups and the mean birth weights of pups from treated bitches in this study was lower than control groups.

These pups grew at a similar rate to control pups. There was a higher incidence of four clinical signs in the lufenuron-treated versus control group: nasal discharge, pulmonary congestion, diarrhea/dehydration and sluggishness. The incidence of these signs was transient and decreasing by the end of lactation. Results from three additional reproductive safety studies, one laboratory and two clinical field studies evaluating eleven breeds of dogs, did not demonstrate any adverse findings for the reproductive parameters measured including fertility, pup birth weights and pup clinical signs after administration of lufenuron up to 5X the recommended monthly use rate.

Data from analysis of milk from lactating animals treated with lufenuron tablets at 2X and 6X the recommended monthly use rate demonstrates that lufenuron concentrates in the milk of these dogs. The average milk:blood concentration ratio was approximately 60 (i.e., 60X higher drug concentrations in the milk compared to drug levels in the blood of treated bitches). Nursing puppies averaged 8-9 times higher blood concentrations of lufenuron compared to their dams.


Sentinel is a registered trademark of Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck & Co. Inc.

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by Novartis

Why Sentinel® Flavor Tabs®?
Choose Sentinel over Trifexis because both products do the same thing but Sentinel is priced at about 1/3 the cost!


Sentinel (milbemycin oxime - lufenuron)
The palatable once-a-month prescription tablet that prevents heartworm disease and flea populations in dogs and puppies. SENTINEL® (milbemycin oxime/lufenuron) Flavor Tabs® also control flea populations and adult hookworms, and remove and control adult roundworm and whipworm infections in dogs and puppies.
 
SENTINEL is indicated for the prevention of heartworm disease (Dirofilaria immitis). SENTINEL kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canisand Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.

Things every pet owner should know about fleas:
  • Fleas can infest your home even in the cold winter months.
  • Fleas picked up outside the home can lead to infestations.
  • All pets in a home should be on flea prevention, even if they spend all their time indoors.
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