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As one of the B-complex vitamins, niacinamide suppresses the inflammatory process, according to the Veterinary Information Network (VIN), and often is used as a first-line approach for autoimmune skin and nail diseases in dogs
Niacinamide generally causes few side effects in dogs, although when it does, those effects can include lethargy and anorexia, according to the website Veterinary Medicine. In some dogs mild gastrointestinal upset--particularly vomiting--also has been seen with the use of niacinamide.
Niacinamide is used in combination with other medications to treat a host of diseases that afflict dogs. Niacinamide is primarily used to treat autoimmune diseases that result in skin conditions, although it is also considered an alternative treatment for other conditions including ones that affect canine feet and eyes. Limited studies of niacinamide as part of a treatment plan show little serious health-related side effects.