NUMELVI (Atinvicitinib Tablets) for Dogs

How to Order Prescriptions

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Description

NUMELVI™ (atinvicitinib tablets) is a prescription medication indicated for the control of itch associated with allergic dermatitis in dogs. Designed specifically for canine use, NUMELVI provides once-daily itch management for dogs experiencing allergic skin conditions under veterinary supervision.

NUMELVI contains atinvicitinib, a Janus kinase (JAK) inhibitor that helps manage itch associated with allergic dermatitis. In clinical studies, atinvicitinib was rapidly absorbed and demonstrated itch relief beginning within 2 to 4 hours in a canine interleukin-31 (IL-31) induced pruritus model.

NUMELVI is administered once daily with food at or around mealtime and is labeled for use in dogs and puppies 6 months of age and older. It may be used alongside many routine veterinary treatments and vaccinations when prescribed by your veterinarian.

Available by prescription only.

Uses & Benefits

Controls itch associated with allergic dermatitis in dogs
Begins providing itch relief within 2 to 4 hours in a canine IL-31-induced pruritus model
Convenient once-daily oral administration
Given with food at or around mealtime
Labeled for dogs and puppies 6 months of age and older
Can be used alongside many routine veterinary treatments and vaccinations
Prescription treatment specifically developed for canine allergic dermatitis management

How It Works

NUMELVI contains atinvicitinib, a Janus kinase (JAK) inhibitor. JAK inhibitors work by targeting signaling pathways involved in the itch response associated with allergic dermatitis. By helping interrupt itch-related signaling, NUMELVI assists in controlling allergic itch and improving comfort in affected dogs.

Indications

NUMELVI™ (atinvicitinib tablets) is indicated for:
Control of itch associated with allergic dermatitis in dogs
Use only as directed by a licensed veterinarian.

Ingredients

Active Ingredient:

Atinvicitinib - Atinvicitinib is a second-generation Janus kinase (JAK) inhibitor developed for the control of itch associated with allergic dermatitis in dogs.

Inactive Ingredients:

Refer to the manufacturer's product insert for the complete inactive ingredient listing. Inactive ingredients may vary by tablet strength and formulation.

Directions

Use only as prescribed by your veterinarian.
Administration Instructions

• Administer orally once daily.
• Give with food at or around mealtime.
• Follow your veterinarian's dosing instructions carefully.
• Complete the prescribed treatment plan unless otherwise directed by your veterinarian.
• If a dose is missed, contact your veterinarian for guidance.

Use only the prescribed tablet strength and dosing schedule provided by your veterinarian.

Cautions

• Federal law restricts this drug to use by or on the order of a licensed veterinarian.
• Not for use in dogs less than 6 months of age.
• Not for use in dogs with serious infections.
• NUMELVI may increase susceptibility to opportunistic infections, including demodicosis and interdigital furunculosis.
• Consider the risks and benefits prior to use in dogs with a history of recurrent demodicosis.
• NUMELVI is a Janus kinase (JAK) inhibitor.
• New neoplastic conditions (benign and malignant) have been reported in dogs treated with other JAK inhibitors.
• The effectiveness and safety of NUMELVI have not been evaluated in a field study beyond 28 days.

See the full prescribing information for complete safety details.

Possible Side Effects:

As with any prescription medication, adverse reactions may occur.
Contact your veterinarian if your dog develops:

• Signs of infection
• New skin abnormalities
• Changes in health status
• Any unexpected or concerning reactions

Consult the product label and your veterinarian for complete safety information.

Precautions

Safe use has not been evaluated in breeding, pregnant, or lactating dogs.
Safe use has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents.
Inform your veterinarian about all medications, supplements, and health conditions before treatment begins.
Regular veterinary monitoring may be recommended during treatment.

Storage

Store at controlled room temperature. Keep in the original container until use. Protect from excessive moisture and heat. Keep out of reach of children and animals.