Trimeprazine with Prednisolone Tablets are a prescription medication for dogs that combine the antipruritic and antitussive properties of trimeprazine with the anti-inflammatory effects of prednisolone. This dual-action formula is commonly prescribed to help manage itching, inflammation, and certain cough conditions in dogs.
The combination may be recommended for dogs experiencing pruritus associated with allergic, parasitic, pustular, or nonspecific dermatitis, as well as selected respiratory conditions where cough suppression and inflammation management are beneficial.
Because underlying causes of itching or coughing may vary, Trimeprazine with Prednisolone should be used under the direction of a licensed veterinarian as part of an individualized treatment plan.
How It Works
Trimeprazine acts as an antipruritic and antitussive agent to help relieve itching and suppress coughs. Prednisolone is a corticosteroid that helps reduce inflammation associated with skin and respiratory conditions. Together, these ingredients provide complementary support for managing itching, inflammation, and certain cough conditions.
Indications
Trimeprazine with Prednisolone is indicated for the relief of pruritus (itching) and inflammation associated with allergic dermatitis and certain inflammatory skin conditions in dogs, as directed by a licensed veterinarian.
Ingredients
Active Ingredients
Each Tablet Contains:
- Trimeprazine Tartrate equivalent to Trimeprazine — 5 mg
- Prednisolone — 2 mg
Inactive Ingredients
Refer to manufacturer packaging for the complete inactive ingredient listing.
Directions
Administer orally as directed by your veterinarian.
The same dosage schedule may be used for both antipruritic and antitussive therapy. Initial treatment is typically administered twice daily, with dosage adjustments based on the individual response of the dog.
After the initial treatment period, your veterinarian may reduce the dosage to the lowest amount necessary to maintain symptom control.
Weight & Dosage
Weight of Dog
Initial Dosage
Up to 10 lbs
1/2 tablet twice daily
11–20 lbs
1 tablet twice daily
21–40 lbs
2 tablets twice daily
Over 40 lbs
3 tablets twice daily
After 4 days, reduce dosage to one-half of the initial dose or to the lowest effective maintenance dose as directed by your veterinarian.
Cautions
- Prescription required
- For use in dogs only.
- Keep out of reach of children and animals.
- Store securely to prevent accidental ingestion or overdose.
- Not for use except under veterinary supervision.
Possible Side Effects
Potential corticosteroid-related side effects may include:
- Increased thirst, Increased urination, Vomiting, Diarrhea, Delayed wound healing, Sodium retention, Potassium loss, Suppressed adrenal function
Potential trimeprazine-related side effects may include:
- Sedation, Protrusion of the third eyelid (nictitating membrane), Increased sensitivity to anesthetics and sedatives
Contact your veterinarian if side effects are severe or persistent.
Precautions
- Use with caution in pregnant animals.
- Corticosteroids administered during pregnancy may increase the risk of fetal abnormalities and premature parturition.
- Long-term therapy should not be discontinued abruptly.
- Gradual withdrawal is recommended following prolonged treatment.
- Monitor for signs of corticosteroid overuse including excessive thirst and urination.
- Dogs with bacterial infections should receive appropriate antimicrobial therapy concurrently when indicated.
- Inform your veterinarian of all medications and supplements your dog is receiving.
Storage
Store at 20°–25°C (68°–77°F). Excursions permitted up to 40°C (104°F).
Protect from light and store in a secure location out of reach of children and animals.