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Phenylpropanolamine (generic for Proin®) is a prescription medication used in dogs for the control of urinary incontinence due to urethral sphincter hypotonus. It contains phenylpropanolamine hydrochloride (PPA), an
alpha-adrenergic agonist that helps improve urethral muscle tone.
Phenylpropanolamine is an adrenergic (alpha-agonist) agent that stimulates receptors in the urethral sphincter muscle. This action increases sphincter tone, helping the bladder retain urine more effectively and reducing leakage.
Phenylpropanolamine Hydrochloride
Typical Dosage:
0.4–0.8 mg per pound of body weight every 12 hours, or as directed by your veterinarian.
Do not exceed 1.8 mg per pound per day unless specifically directed by your veterinarian.
Possible side effects may include:
Serious Reactions:
Discontinue use and contact your veterinarian immediately if signs of an allergic reaction occur, including:
Store securely—accidental ingestion of large quantities may result in overdose.
Store at controlled room temperature 20°–25°C (68°–77°F).
Excursions permitted between 15°–40°C (59°–104°F).
Keep tightly closed and out of reach of children and animals.