10 Doses - Individual Doses
50 Doses - Individual Doses
SKU : 46710_-RX
Price: $117.99

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  • Aids in the reduction in the incidence of clinical mastitis in the first 30 days of lactation in dairy cows and replacement dairy heifers.
How to Order Prescriptions


Imrestor is FDA approved for the reduction in the incidence of clinical mastitis in the first 30 days of lactation in dairy cows and replacement dairy heifers. Imrestor is a protein that helps support the natural function of a dairy cow’s immune system during the critical time around calving, when she is most vulnerable to mastitis.

Dosage & Administration

This is a two-dose regimen. The same dose is used regardless of cow/heifer body weight. Remove surface dirt from the injection site area before injecting. Inject the entire contents of the syringe subcutaneously. Do not reuse the syringe.

Administer the first dose (syringe) 7 days prior to the cow's or heifer's anticipated calving date. If necessary, the first dose may be administered within a range of 4 to 10 days prior to the anticipated calving date to accommodate management schedules. Administer the second dose (syringe) within 24 hours after calving.

Animals that calve either less than or more than 7 days after the first dose should receive the second dose within 24 hours after calving.

Prior to administration, Imrestor should be visually inspected for particulate matter and discoloration. Imrestor is a clear, colorless solution and may contain a few small, translucent or white particles. Imrestor should not be used if it is discolored or cloudy, or if other particulate matter is present. Do not shake or tap the syringe prior to use.

Residue Warning

No withdrawal period or milk discard time is required when used according to the labeling.

Human Warnings

Not for use in humans. Keep out of reach of children.

User Safety Warnings

In case of accidental self-injection, wash the site of injection thoroughly with clean running water. Foreign proteins such as pegbovigrastim have the potential to cause anaphylactic-type reactions. If you experience swelling or redness at the site of exposure, or more severe reactions such as shortness of breath, seek medical attention immediately and take the package insert with you. Report the event to Elanco Animal Health at 1-800-428-4441. To obtain a Safety Data Sheet, contact Elanco Animal Health at 1-800-428-4441.


Do not use Imrestor to treat cows with clinical mastitis because effectiveness has not been demonstrated for this use.

Adverse Reactions

Some cases of hypersensitivity-type reactions have been observed in studies outside the United States within five minutes to two hours, occurring most often after the first administration of Imrestor. Clinical signs may include elevated respiratory rate, dyspnea, urticaria, sweating, dependent edema, swollen mucous membranes, and/or hypersalivation, and, rarely death. These reactions resolve within hours of onset with or without therapeutic intervention and have not been shown to reoccur with subsequent injections of Imrestor. Abomasal ulcerations/erosions were observed in the Margin of Safety studies. (See Target Animal Safety section).

by Elanco

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