Vetoryl Capsules

Vetoryl Capsules
5 mg, Single - Capsule 
5 mg, 30 ct. - Capsule
10 mg, Single - Capsule
10 mg, 30 ct. - Capsule
30 mg, Single - Capsule
30 mg, 30 ct. - Capsule
60 mg, Single - Capsule
60 mg, 30 ct. - Capsule
120 mg, Single - Capsule
120 mg, 30 ct. - Capsule
SKU : 300705-EA_-RX
Price: $1.20

Veterinarian Prescription (Rx) Required
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  • Trilostane
  • Adrenocortical suppressant
  • Treats Cushing’s syndrome in dogs
  • For oral use in dogs only
RX required for this item. 
Click here for our full Prescription Policy and Form

Why VETORYL Capsules?

  • Contain the active ingredient trilostane.
  • Trilostane blocks the excessive production of cortisol by reversibly inhibiting the action of the enzyme 3-ß hydroxysteroid dehydrogenase.
  • While treatment with trilostane significantly reduces serum cortisol concentrations, it has not been found to reduce aldosterone significantly.†

Adrenocortical suppressant for oral use in dogs only.


VETORYL Capsules are available in 3 sizes (10, 30 and 60 mg) for oral administration based on body weight. Trilostane (4α, 5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone. This inhibition blocks production of glucocorticoids and to a lesser extent, mineralocorticoids and sex hormones while steroid precursor levels increase.


  • VETORYL Capsules are indicated for the treatment of pituitary-dependent hyperadrenocorticism in dogs.
  • VETORYL Capsules are indicated for the treatment of hyperadrenocorticism due to adrenocortical tumor in dogs.


Always provide the Client Information Sheet with prescription. The starting dose for the treatment of hyperadrenocorticism in dogs is 1.0-3.0 mg/lb (2.2-6.7 mg/kg) once a day based on body weight and capsule size (see Table 1). VETORYL Capsules should be administered with food.


After approximately 10-14 days at this dose, re-examine the dog and conduct a 4-6 hour post-dosing ACTH stimulation test and serum biochemical tests (with particular attention to electrolytes, and renal and hepatic function). If physical examination is acceptable, take action according to Table 1.

Owners should be instructed to stop therapy and contact their veterinarian immediately in the event of adverse reactions such as vomiting, diarrhea, lethargy, poor/reduced appetite, weakness, collapse or any other unusual developments. If these clinical signs are observed, conduct an ACTH stimulation test and serum biochemical tests (with particular attention to electrolytes, and renal and hepatic function


by Dechra

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