Generlac Solution 10 g/15 mL

Generlac Solution
SKU : 43191_-RX
Price: $9.95

Veterinarian Prescription (Rx) Required
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  • A colonic acidifier for treatment and prevention of portal-systemic encephalopathy
  • A synthetic disaccharide in solution form for oral or rectal administration
  • Available Sizes: 16 fl oz (473 mL) and 2 Quarts (1892 mL)
RX required for this item. 
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Generlac Solution (Lactulose Solution, USP) is a synthetic disaccharide in solution form for oral or rectal administration. Each 15 mL of Generlac Solution contains: 10 g lactulose (and less than 1.6 g galactose, less than 1.2 g lactose, less than 0.8 g epilactose and 0.1 g or less of fructose). The pH range is between 2.5 and 6.5.

Generlac Solution is a colonic acidifier for treatment and prevention of portal-systemic encephalopathy.

Adult  Pediatric
The usual adult oral dosage is 2 to 3 tablespoonfuls (30 to 45 mL, containing 20 g to 30 g of Generlac
Solution) three or four times daily. The dosage may be adjusted every day or two to produce 2 or 3 soft
stools daily.

Hourly doses of 30 to 45 mL of Generlac Solution may be used to induce the rapid laxation indicated in
the initial phase of the therapy of portal-systemic encephalopathy. When the laxative effect has been
achieved, the dose of Generlac Solution may then be reduced to the recommended daily dose.
Improvement in the patient's condition may occur within 24 hours but may not begin before 48 hours or
even later.

Continuous long-term therapy is indicated to lessen the severity and prevent the recurrence of portalsystemic
encephalopathy. The dose of Generlac Solution for this purpose is the same as the
recommended daily dose.
 Very little information on the use of lactulose in young children and adolescents has been recorded. As
with adults, the subjective goal in proper treatment is to produce 2 to 3 soft stools daily. On the basis of
information available, the recommended initial daily oral dose in infants is 2.5 to 10 mL in divided
doses. For older children and adolescents, the total daily dose is 40 to 90 mL. If the initial dose causes
diarrhea, the dose should be reduced immediately. If diarrhea persists, Generlac Solution should be

When the adult patient is in the impending coma or coma stage of portal-systemic encephalopathy and
the danger of aspiration exists, or when the necessary endoscopic or intubation procedures physically
interfere with the administration of the recommended oral doses, Generlac Solution may be given as a
retention enema via a rectal balloon catheter. Cleansing enemas containing soapsuds or other alkaline
agents should not be used.

Three hundred mL of Generlac Solution should be mixed with 700 mL of water or physiologic saline
and retained for 30 to 60 minutes. Generlac Solution enema may be repeated every 4 to 6 hours. If the
enema is inadvertently evacuated too promptly, it may be repeated immediately.

The goal of treatment is reversal of the coma stage in order that the patient may be able to take oral
medication. Reversal of coma may take place within 2 hours of the first enema in some patients.
Generlac Solution, given orally in the recommended doses, should be started before Generlac Solution
by enema is stopped entirely.

Generlac Solution (Lactulose Solution, USP, 10 g/15 mL) is a colorless to yellow, unflavored solution
containing 10 g of lactulose/15 mL (667 mg lactulose/mL). It is available in the following container
  • 1 Pint (473 mL) bottles (NDC 60432-038-16)
  • 2 Quart (1892 mL) bottles (NDC 60432-038-64)
Store at 20° to 25°C (68° to 77°F) [s ee USP Controlled Room Temperature].
Do Not Freeze
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