Clavamox Drops for Cats and Dogs
SKU: 2945-RX
- 15ml bottle
- Veterinarian Prescription (Rx) Required
- Free Shipping on orders over $75
- 50 mg of amoxicillin as the trihydrate when reconstituted
- 12.5 mg of clavulanic acid as the potassium salt when reconstituted
- Drops (liquid)
- For use in Cats and Dogs
Price: $15.95
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by Pfizer
Clavamox®
(amoxicillin/clavulanic acid)
Veterinary tablets and drops for use in dogs and cats
DESCRIPTION: CLAVAMOX (amoxicillin trihydrate/clavulanate potassium) is an orally administered formulation comprised of the broad-spectrum antibiotic Amoxi® (amoxicillin trihydrate) and the ß-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Amoxicillin trihydrate is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many Gram-positive and Gram-negative, aerobic and anaerobic microorganisms. It does not resist destruction by ß-lactamases; therefore, it is not effective against ß-lactamase-producing bacteria. Chemically, it is d(-)-a-amino-p-hydroxybenzyl penicillin trihydrate. Clavulanic acid, an inhibitor of ß-lactamase enzymes, is produced by the fermentation of Streptomyces clavuligerus. Clavulanic acid by itself has only weak antibacterial activity. Chemically, clavulanate potassium is potassium z-(3R,5R)-2 ß-hydroxyethylidene clavam-3-carboxylate.
CLINICAL PHARMACOLOGY: CLAVAMOX is stable in the presence of gastric acid and is not significantly influenced by gastric or intestinal contents. The 2 components are rapidly absorbed resulting in amoxicillin and clavulanic acid concentrations in serum, urine, and tissues similar to those produced when each is administered alone. Amoxicillin and clavulanic acid diffuse readily into most body tissues and fluids with the exception of brain and spinal fluid, which amoxicillin penetrates adequately when meninges are inflamed. Most of the amoxicillin is excreted unchanged in the urine. Clavulanic acid’s penetration into spinal fluid is unknown at this time. Approximately 15% of the administered dose of clavulanic acid is excreted in the urine within the first 6 hours. CLAVAMOX combines the distinctive properties of a broad-spectrum antibiotic and a ß-lactamase inhibitor to effectively extend the antibacterial spectrum of amoxicillin to include ß-lactamaseproducing as well as non-ß-lactamase-producing aerobic and anaerobic organisms.
*The susceptibility of these organisms has also been demonstrated in in vivo studies. Studies have demonstrated that both aerobic and anaerobic flora are isolated from gingival cultures of dogs with clinical evidence of periodontal disease. Both Gram-positive and Gram-negative aerobic and anaerobic subgingival isolates indicate sensitivity to amoxicillin/clavulanic acid during antimicrobial susceptibility testing.
INDICATIONS AND USAGE: CLAVAMOX Tablets and Drops are indicated in the treatment of:
Dogs: Skin and soft-tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep pyoderma due to susceptible strains of the following organisms: ß-lactamase-producing Staphylococcus aureus, non-ß-lactamase-producing Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., and E. coli. Periodontal infections due to susceptible strains of both aerobic and anaerobic bacteria. CLAVAMOX has been shown to be clinically effective for treating cases of canine periodontal disease.
Cats: Skin and soft-tissue infections such as wounds, abscesses, and cellulitis/dermatitis due to susceptible strains of the following organisms: ß-lactamase-producing Staphylococcus aureus, non-ß-lactamase-producing Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., E. coli, and Pasteurella spp. Urinary tract infections (cystitis) due to susceptible strains of E. coli. Therapy may be initiated with CLAVAMOX prior to obtaining results from bacteriological and susceptibility studies. A culture should be obtained prior to treatment to determine susceptibility of the organisms to CLAVAMOX. Following determination of susceptibility results and clinical response to medication, therapy may be reevaluated.
DOSAGE AND ADMINISTRATION
Dosage and Directions for Use of CLAVAMOX Tablets and CLAVAMOX Drops:
Dogs: The recommended dosage for CLAVAMOX Tablets is 6.25 mg/lb of body weight twice a day. The recommended dosage for CLAVAMOX Drops is 6.25 mg/lb (1 mL/10 lb) of body weight twice a day. Skin and soft-tissue infections such as abscesses, cellulitis, wounds, superficial/juvenile pyoderma, and periodontal infections should be treated for 5–7 days or for 48 hours after all symptoms have subsided. If no response is seen after 5 days of treatment, therapy should be discontinued and the case reevaluated. Deep pyoderma may require treatment for 21 days; the maximum duration of treatment should not exceed 30 days.
Cats: The recommended dosage for CLAVAMOX Tablets is 62.5 mg twice a day. The recommended dosage for CLAVAMOX Drops is 62.5 mg (1 mL) twice a day. Skin and soft-tissue infections such as abscesses and cellulitis/dermatitis should be treated for 5–7 days or for 48 hours after all symptoms have subsided, not to exceed 30 days. If no response is seen after 3 days of treatment, therapy should be discontinued and the case reevaluated. Urinary tract infections may require treatment for 10–14 days or longer. The maximum duration of treatment should not exceed 30 days. Reconstitution Instructions — Oral Suspension: Add 14 mL of water to the 15 mL bottle and shake vigorously. Each mL of suspension will contain 50 mg of amoxicillin activity as the trihydrate and 12.5 mg of clavulanic acid activity as the potassium salt.
Note: Any unused portion of the reconstituted suspension must be discarded after 10 days. Refrigeration of the reconstituted suspension is required.
CLAVAMOX Tablets should be stored in a dry, cool place at temperatures not above 25°C (77°F). Do not remove from foil strip until ready to use.
CONTRAINDICATIONS: The use of this drug is contraindicated in animals with a history of an allergic reaction to any of the penicillins or cephalosporins.
WARNINGS: Safety of use in pregnant or breeding animals has not been determined.
ADVERSE REACTIONS: CLAVAMOX contains a semisynthetic penicillin (amoxicillin) and has the potential for producing allergic reactions. If an allergic reaction occurs, administer epinephrine and/or steroids.
